10/26/22 Review of Medical Patent. Korean to English, Dallas, Texas
A method for terminally sterilizing a pre-filled syringe comprising
i) providing a syringe comprising a body and a stopper, wherein the body comprises an outlet at the outlet end, and the stopper is arranged within the body in a manner that the front surface of the stopper and the body form a variable volume chamber to discharge fluid from the variable volume chamber through the outlet, wherein the outlet is sealed in a manner that it can be dissembled, and the variable volume chamber contains an injectable ophthalmic medicine, the stopper comprises a circumferential front rib and a circumferential rear rib that are separated from each other by at least 3 mm in a direction along the first axis, the syringe further comprises a plunger comprising a plunger contact surface of the first end, and a rod extending between the plunger contact surface and the rear portion, the rear surface of the stopper comprises a central depression, and the syringe is dimensioned to have a nominal maximum fill volume of 0.4 ml to 0.6 ml; and
ii) terminally sterilizing a syringe, wherein the terminally sterilized syringe is obtained by sterilizing a syringe sealed in a package, the pressure changes within or outside the variable volume chamber, and the injectable ophthalmic medicine contains air bubbles that can change in volume and enable the stopper to move.